出版伦理

本预印本的所有作者共同声明，严格遵守学术研究伦理及预印本出版相关规范，具体承诺如下：

原创性与未发表声明：本预印本所呈现的研究成果为作者独立完成的原创性工作，未被任何期刊、会议或其他出版平台正式发表（以预印本形式在合规平台存档除外），不存在一稿多投、重复发表等问题。

数据与方法真实性：研究数据真实、完整，实验方法规范可重复，所有图表、统计结果均基于实际研究过程记录，未进行伪造、篡改或选择性呈现；若涉及二次数据分析，已获得原始数据使用授权。

版权与授权合规：预印本内容（包括文本、图表、数据等）未侵犯任何第三方的版权、专利或其他知识产权；引用他人研究成果、受版权保护的材料（含互联网资源）时，已规范标注来源，并获得必要的使用授权。本预印本的共享遵循知识共享相关许可协议，任何机构或个人引用、传播本预印本需遵守相应许可条款。

利益冲突披露：所有作者已如实披露与本研究相关的潜在利益冲突（包括但不限于受雇关系、咨询服务、股权持有、资助支持、专利申请等）；若不存在利益冲突，特此声明：“全体作者均无与本研究相关的利益冲突需披露”。

作者资格合规：所有署名作者均满足学术署名规范，对研究设计、数据收集、分析、撰写及修改等关键环节作出实质性贡献，并已审阅预印本全文，同意其在预印本平台发布；不存在虚假署名、遗漏核心贡献者或未经同意擅自署名等情况。

伦理审查合规：若研究涉及人类受试者、动物实验、临床数据或敏感生物材料，已获得相关伦理审查委员会（IRB/IACUC）的批准或豁免，严格遵循医学伦理、动物福利等相关法规，所有受试者已签署知情同意书（如适用）。

引用规范与学术诚信：文中所有引用的文献、观点、数据均已准确标注来源，不存在剽窃、抄袭他人研究成果的行为；对他人研究的引用客观公正，未进行歪曲或断章取义。

后续发表承诺：本预印本在预印本平台发布后，若后续向正式期刊投稿，将如实告知期刊编辑部本预印本的存档情况，遵循目标期刊关于预印本投稿的相关政策；若研究内容发生实质性修改（如数据补充、结论调整），将在后续版本或正式发表论文中明确说明。

全体作者确认，已充分理解并遵守上述伦理承诺，对本预印本的学术诚信与伦理合规性承担共同且连带责任；如违反上述声明，自愿承担由此产生的一切学术后果与法律责任。

All authors of this preprint collectively declare that they strictly adhere to academic research ethics and relevant norms for preprint publication, with the following specific commitments:

Statement on Originality and Unpublished Status

The research results presented in this preprint are original work independently completed by the authors. It has not been formally published in any journal, conference, or other publishing platform (except for archiving as a preprint on compliant platforms), and there are no issues such as multiple submissions or duplicate publication.

Authenticity of Data and Methods

The research data is true and complete, and the experimental methods are standardized and reproducible. All figures, tables, and statistical results are based on actual research records, without forgery, falsification, or selective presentation. If secondary data analysis is involved, authorization for the use of original data has been obtained.

Compliance with Copyright and Authorization

The content of this preprint (including text, figures, data, etc.) does not infringe upon the copyright, patents, or other intellectual property rights of any third party. When citing others' research results or copyrighted materials (including internet resources), the sources have been properly cited, and necessary authorization for use has been obtained. The sharing of this preprint complies with relevant Creative Commons (CC) license agreements. Any institution or individual citing or disseminating this preprint must abide by the corresponding license terms.

Disclosure of Conflicts of Interest

All authors have truthfully disclosed potential conflicts of interest related to this research (including but not limited to employment relationships, consulting services, equity holdings, funding support, patent applications, etc.). If there are no conflicts of interest, it is hereby stated: "All authors declare no conflicts of interest related to this research."

Compliance with Authorship Criteria

All listed authors meet the academic authorship standards, have made substantial contributions to key links such as research design, data collection, analysis, writing, and revision, have reviewed the full text of the preprint, and agreed to its publication on the preprint platform. There are no circumstances such as false authorship, omission of core contributors, or unauthorized authorship without consent.

Compliance with Ethical Review

If the research involves human subjects, animal experiments, clinical data, or sensitive biological materials, approval or exemption from the relevant Institutional Review Board (IRB) or Institutional Animal Care and Use Committee (IACUC) has been obtained. The research strictly adheres to relevant regulations on medical ethics and animal welfare, and all human subjects have signed informed consent forms (if applicable).

Citation Norms and Academic Integrity

All cited literatures, viewpoints, and data in the preprint have been accurately attributed, and there is no plagiarism of others' research results. Citations of others' research are objective and fair, without distortion or taking out of context.

Commitment to Subsequent Publication

After the preprint is published on the preprint platform, if it is subsequently submitted to a formal journal, the authors will truthfully inform the journal editorial office of the archiving status of this preprint and comply with the target journal's relevant policies on preprint submissions. If there are substantial revisions to the research content (such as supplementary data or adjustment of conclusions), it will be clearly stated in subsequent versions or formally published papers.

All authors confirm that they have fully understood and will abide by the above ethical commitments, and jointly and severally assume responsibility for the academic integrity and ethical compliance of this preprint. If any of the above statements are violated, the authors voluntarily assume all resulting academic and legal responsibilities.